June 2006 Archives
Google Trends provee información sobre los patrones de búsquedas en Google...
De acuerdo a ésta gráfica Felipe Calderón lleva la delantera.
Ver gráfica via Google Trends aquí.
"If God had wanted us to vote, he would have given us candidates."
- Jay Leno
PGD is now PGH
New technique being used at Guy’s and St Thomas’ NHS Foundation Trust in England.
PGH involves clinicians firstly amplifying the DNA from the single cell they have extracted from the embryo to replicate the cell’s genetic material by a million times. DNA finger printing is then used on the cells. This finger printing enables them to distinguish between the chromosomes carrying the affected gene and those that do not. This means that they can track the affected gene without having to look at the actual mutation.
More via Guy's and St. Thomas' here.
Javier y Patricia Aja,
Les mandamos todo nuestro cariño.
No hay nada que pueda yo decir para remediar la perdida pero queremos que sepan que estamos pensando mucho en ustedes. Deseamos que sus Amigos y Familia los apapachen muchisimo!
Hay mucho por hacer y espero conocerlos en persona pronto.
Andrés L. Treviño
Boost the levels of a gene called NANOG inside a embryonic stem cell, fuse it with a brain cell and the brain cell converts into a stem cell.
The researchers believe that Nanog, alongside other genes, kicks into action a cascade of complex biological machinery that forces cells back into their simplest state, before they have gone down the path of becoming one of the 200 cell types found in the body.
Read the article via The Guardian here.
Lack of Human Eggs Could Hamper US Cloning Efforts
Researchers want to make patient-matched stem cells, but success could depend on gaining a reliable source of human eggs.
...Unlike other embryonic stem cell research, these experiments require unfertilized human eggs. The egg donation procedure is uncomfortable, potentially painful, and carries some medical risk. Women must undergo hormone treatments to stimulate ovulation, counseling sessions to understand the risks involved, and a medical procedure in which a needle is inserted into the vagina to remove eggs from the ovary. A small percentage of donors develop ovarian hyperstimulation syndrome, which in rare cases can cause kidney damage....
More via MIT Technology Review here.
Dr. Jordan S. Orange said today,
The lab is very busy - Making some headway on the NEMO projects. We have successfully subcloned a number of different NEMO mutations found in disease to try and learn more about how they specifically impair
NF-kB function.
More about Orange Lab here.
From the Pediatrics Journal, published today:
Successful Allogeneic Hemopoietic Stem Cell Transplantation in a Child Who Had Anhidrotic Ectodermal Dysplasia With Immunodeficiency
Sophie Dupuis-Girod, MDa,b, Caterina Cancrini, MD, PhDc, Françoise Le Deist , MD, PhDd,1, Paolo Palma, MDc, Christine Bodemer, MDe, Anne Puel, PhDf, Susanna Livadiotti, MDc, Capucine Picard, MDa, Xavier Bossuyt, MD, PhDg, Paolo Rossi, MD, PhDc, Alain Fischer, MD, PhDa,h and Jean-Laurent Casanova, MD, PhDa,f
a Unité d'Immunologie et d'Hématologie Pédiatriques
d Centre d'études des Déficits Immunitaires
e Service de Dermatologie
h Développement Normal et Pathologique du Système Immunitaire, Institut National de la Santé et de la Recherche Médicale U429, Hôpital Necker-Enfants Malades, Paris, France
b Service de Génétique, Hospices Civils de Lyon, Hôpital de l'Hotel Dieu, Lyon, France
c Division of Immunology and Infectious Disease, Bambino Gesù Children's Hospital, University of Rome Tor Vergata, Rome, Italy
f Laboratoire de Génétique Humaine des Maladies Infectieuses, Université René Descartes-Institut National de la Santé et de la Recherche Médicale U550, Faculté de Médecine Necker-Enfants Malades, Paris, France
g Laboratory of Experimental Medicine, University Hospital Leuven, Leuven, Belgium
Anhidrotic ectodermal dysplasia with immunodeficiency is associated with multiple infections and a poor clinical outcome. Hypomorphic mutations in nuclear factor {kappa}B essential modulator (NEMO)/I{kappa}B kinase complex and a hypermorphic mutation in inhibitor {alpha} of nuclear factor {kappa}B (I{kappa}B{alpha}) both result in impaired nuclear factor {kappa}B activation and are associated with X-recessive and autosomal-dominant forms of anhidrotic ectodermal dysplasia with immunodeficiency, respectively. Autosomal-dominant anhidrotic ectodermal dysplasia with immunodeficiency is also associated with a severe T-cell phenotype. It is not known whether hematopoietic stem cell transplantation can cure immune deficiency in children with anhidrotic ectodermal dysplasia with immunodeficiency. A boy with autosomal-dominant anhidrotic ectodermal dysplasia with immunodeficiency and a severe T-cell immunodeficiency underwent transplantation at 1 year of age with haploidentical T-cell–depleted bone marrow after myeloablative conditioning. Engraftment occurred, with full hematopoietic chimerism. Seven years after transplantation, clinical outcome is favorable, with normal T-cell development. As expected, the developmental features of the anhidrotic ectodermal dysplasia syndrome have appeared and persisted. This is the first report of successful hematopoietic stem cell transplantation in a child with anhidrotic ectodermal dysplasia with immunodeficiency. Hematopoietic stem cell transplantation is well tolerated and efficiently cures the profound immunodeficiency associated with autosomal-dominant anhidrotic ectodermal dysplasia with immunodeficiency.
Meet "Cooper the Trooper".
Cooper had NEMO deficiency and was transplanted May 2nd, 2006 with stem cells from his Dad.
Read Cooper the Trooper blog here.
Via Flora Bergeron.
Jacarandas y Seris
Col. La Raza C.P. 02990
Teléfono 5724 5900 ext. 24212 o 24259
Gracias a Maria Elena Maza y Sergio Méndez
Jack will be on TV!
More about Jack here.
Discovery Health Channel / Mystery Diagnosis next Monday June 12, 2006.
Program Name: Discovery Channel Mystery Diagnosis
The Man with Rocks in His Chest
Charlotte and Roy Hagelin are overjoyed when they give birth to their second child Jack. But just two weeks after his birth, joy turns to horror when Jack is stricken with nonstop vomiting. He soon becomes malnourished. Can doctors diagnose Jack in time
More information here.
Joe Shortsleeve, Chief Correspondent CBS 4 News Boston will be here in about 45 minutes for an interview.
Harvard and Children's Hospital Boston announced a few minutes ago the advances in stem cell research..
More about the announcement here.
I will try to talk about the following during the interview:
STEM CELLS SAVE LIVES
And more details soon...
More about Joe here.
Ya está lista la quiniela.
$25 dólares por quiniela.
Premio = $2 dólares x número de quinielas dadas de alta.
Fondos a "The Andy Fund for Immune Deficiency Research", Children's Hospital Boston.
After 81 days in the hospital, Jack is going home with a new immune system! He lives IMMUNE!
Go Jack!
