NEMO Patents

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Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain

Abstract
The invention includes compositions and methods for the selective inhibition of cytokine-mediated NF-κB activation by blocking the interaction of NEMO with IκB kinase-β (IKKβ) at the NEMO binding domain (NBD). The blockade of IKKβ-NEMO interaction resulting in inhibition of IKKβ kinase activity and subsequent decreased phosphorylation of IκB. Phosphorylation of IκB being an integral step in cytokine-mediated NF-κB activation. The invention further includes methods for screening for agents capable of interacting at the NBD and therapeutic uses for such agents in pathological disorders caused by dysregulation of NF-κB activation.

Patent number: 6864355
Filing date: Aug 22, 2000
Issue date: Mar 8, 2005
Inventors: Michael J. May, Sankar Ghosh
Assignee: Yale University
Primary Examiner: Jon Weber
Secondary Examiner: Rita Mitra
Attorneys: Lahive & Cockfield, LLP, Giulio A. DeConti, Jr., Maria Laccotripe Zacharakis

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